Seneca may refer to:
- Seneca Lake, the largest Finger Lake
- Seneca Lake Wine Trail
- Seneca Falls, village near the North end of Cayuga Lake
- Seneca County, located between Seneca Lake and Cayuga Lake
- Seneca Meadows Landfill; the largest landfill in New York State
- Seneca Transfer Station; a local dump in the Town of Seneca
- Seneca Street in Geneva